hrp0097ha1 | An integrated roadmap of human fetal adrenal gland development | ESPE2023

An integrated roadmap of human fetal adrenal gland development

del Valle Ignacio , Young Matthew , Kildisiute Gerda , Ogunbiyi Olumide , Buonocore Federica , Simcock Ian , Khabirova Eleonora , Crespo Berta , Moreno Nadjeda , Brooks Tony , Niola Paola , Swarbrick Katherine , Suntharalingham Jenifer , McGlacken-Byrne Sinead , Arthurs Owen , Behjati Sam , Achermann John

Introduction: The human adrenal gland originates from the adrenogonadal primordium at around 4 weeks post conception (wpc) and undergoes marked developmental changes throughout the first half of pregnancy. Several key aspects of adrenal maturation are well-established, such as the formation of a large inner fetal zone (FZ) and synthesis of dehydroepiandrosterone, but many other processes contributing to adrenal gland development and function in humans are stil...